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Iron deficiency alters DMBA-induced tumor burden and natural killer cell cytotoxicity in rats

Article Abstract:

The influence of iron deficiency on the cytotoxicity of natural killer (NK) cells is investigated in rats fed graded amounts of iron and injected with the carcinogen, 7,12-dimethylbenz-a-anthracene (DMBA). Test animals were sacrificed one to several weeks after DMBA challenge and NK cell activity and tumor prevalence were assessed. Results showed that moderate iron deficiency reduces NK cell cytotoxicity and increases the incidence of tumor. On the other hand, severe iron deficiency impaired NK cells but did not increase tumor incidence as much as moderate iron deficiency had.

Health aspects, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Killer cells

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The mechanisms of nonheme iron uptake determined in IEC-6 rat intestinal cells

Article Abstract:

An in vitro model system to study the uptake of iron in enterocytes was developed. The system consists of the rat small intestinal epithelial cell strain IEC-6 grown in Dulbecco's Modified Eagle Medium with or without iron supplement. The cells can be grown to confluency, and electron microscopy showed that the monolayer cells are polarized and contain both microvilli and tight junctions. The system also expressed iron-binding proteins and could be used to characterize the metabolic pathways for iron uptake.

Research, Transferrin, Absorption, Cell culture, Tissue culture

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