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Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc in rats

Article Abstract:

The regulatory role of dietary zinc on the expression of metallothionein gene expression was examined in rats on zinc diets. Nuclear fractions of various tissue homogenates were analyzed to determine the zinc accumulation rates. Results showed that the accumulated zinc binds to nuclear proteins, particularly the metallothionein gene promoter. Northern blot analysis of messenger RNAs (mRNA) revealed that metallothionein gene expression was directly correlated to zinc uptake in the kidney, liver, intestine, spleen and heart. However, no significant increase in metallothionein mRNA was observed in the lungs and thymus.

Research, Genetic regulation, Metallothionein

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James Smith Dinning (1922-1991)

Article Abstract:

James Smith Dinning was born on Sep. 28, 1922, in Logan County, KY. He obtained his secondary education from Middleton High School in 1939 and enrolled at the University of Kentucky in the same year. In 1942, he was drafted into the US Army and was forced to stop his schooling. In 1944, he married Sally Sue Hensley and two years later, pursued graduate studies at Oklahoma A&M College, where he majored in biochemistry. He was awarded a PhD degree by the university in 1948. During the 1950s, he traveled to several countries including Thailand where he helped educational programs in nutrition and agriculture.

Obituary, Biochemists, Dinnings, James Smith

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Cysteine-rich intestinal protein and intestinal metallothionein: an inverse relationship as a conceptual model for zinc absorption in rats

Article Abstract:

Intestinal zinc uptake in rats fed with low- and high-zinc diets was examined to determine the role of cysteine-rich intestinal protein (CRIP) and metallothionein in zinc absorption. Results showed that zinc concentration did not affect CRIP levels, however, higher zinc concentration induced a reduction in CRIP-bound zinc in the cytoplasm of enterocytes. This indicate that the zinc transport protein, CRIP, can be saturated and that metallothionein reduce zinc uptake by competing with CRIP in binding zinc. A model representing transcellular zinc uptake is discussed.

Models, Carrier proteins, Transport proteins, Intestinal absorption

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