Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog
Article Abstract:
The rate of removal (clearance) of Atrial Natriuretic Factor (ANF) from the blood after passage through various organs, in both humans and dogs. (ANF is a protein secreted into the blood by cells in the wall of the right chamber in the heart of mammals. ANF is carried to the kidney by the blood system where it increases the secretion of sodium.) The concentration of ANF after the blood had passed through the lungs was measured and compared to the concentration before entering the lungs. There was found to be 24 percent less ANF after the blood had passed through the lungs of humans. A similar clearance was found in the lungs of dogs. Even higher ratios were found for the liver and kidney. These data establish clearance values for specific organs and provide a rationale for evaluating levels of ANF for diseased states.
Publication Name: Journal of Clinical Investigation
Subject: Health care industry
ISSN: 0021-9738
Year: 1989
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Dissociation of natriuresis and diuresis and heterogeneity of the effector system of atrial natriuretic factor in rats
Article Abstract:
Atrial Natriuretic Factor, ANF, is a protein secreted into the blood by a collection of cells in the wall of the right heart chamber in mammals. ANF is carried to the kidney in the blood where it influences the secretion rate of sodium, and increases the rate of urination. ANF also decreases blood pressure in part by decreasing resistance of blood vessels walls. Accompanying these effects, a specific compound cyclic monophosphate (cGMP) level is raised both in the blood and urine. However a compound related to ANF, Met-O-ANF, is unable to increase cGMP. The authors study the different actions of ANF and Met-O-AMF in rats.
Publication Name: Journal of Clinical Investigation
Subject: Health care industry
ISSN: 0021-9738
Year: 1989
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Hepatic oleate uptake. Electrochemical driving forces in intact rat liver
Article Abstract:
This experiment studies the uptake of the fatty acid, oleate in rats. A small electrical probe, was guided by a microscope into a single liver cell. The experimenters were able to control the electrochemical force. The results suggest that a portion of oleate uptake by intact rat liver is driven by both the electrical field and sodium concentration across the liver cell membrane.
Publication Name: Journal of Clinical Investigation
Subject: Health care industry
ISSN: 0021-9738
Year: 1989
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