A knockout of a transgenic mouse - animal models of sickle cell anemia

Article Abstract:

There are four transgenic mouse models that can be used to study sickle cell anemia. Transgenic mice contain human genes in addition to their own. All four models carry the sickle gene, which affects the beta chain of hemoglobin. Three models also carry mouse globin genes. These animals have less severe disease because the mouse globin compensates for the sickle human hemoglobin. It may be impossible to create a mouse model that mimics sickle cell anemia perfectly, because many more genes contribute to the disease.

Models, Usage, Genetically modified mice

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The Challenge of Painful Crisis in Sickle Cell Disease

Article Abstract:

Researchers continue to search for a drug or substance that can prevent sickled blood cells from clumping together in small blood vessels and capillaries. When this happens, the tissue supplied by the capillaries does not receive enough oxygen. This causes severe pain and is called a sickle cell crisis.

Editorial, Drug therapy

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Update: Newborn Screening for Sickle Cell Disease--California, Illinois, and New York, 1998

Article Abstract:

It may be difficult to contact families of children who were screened at birth for sickle cell anemia to make sure the child receives adequate care. In a follow-up study of children diagnosed at birth with sickle cell anemia in 1992-1993, only 24% of the parents could be contacted by phone.

Care and treatment, Research, Medical screening, Health screening

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