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A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents

Article Abstract:

Antiplatelet therapy may be more effective than standard anticoagulant therapy in preventing complications after the stent placement following coronary angioplasty. Antiplatelet therapy blocks the formation of platelets, which activate the clotting procedure. Researchers compared the number of complications after stent placement in 257 patients receiving antiplatelet therapy and 260 patients receiving traditional anticoagulant therapy. The antiplatelet combination to ticlopidine and aspirin was superior to the anticoagulant combination of intravenous heparin, phenprocoumon, and aspirin. Anti-platelet patients had a much lower risk of heart attack and less need for repeated procedures. Stent occlusion occurred in 0.8% of the antiplatelet patients compared to 5.4% in the patients receiving anticoagulants. A small number of patients in the anticoagulant group, but none of the antiplatelet patients, had bleeding episodes.

Complications and side effects, Thrombosis, Stent (Surgery), Stents, Angioplasty, Ticlopidine

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Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery

Article Abstract:

A controlled study was conducted to evaluate the hemostatic (stoppage of hemorrhage) effect of tranexamic acid mouthwash in patients receiving anticoagulant (anti-clotting) therapy and who are undergoing oral surgery. Bleeding occurred in 40 percentof the patients in the placebo group as compared to less than 5 percent of the patients receiving tranexamic acid therapy. The study demonstrates a significant hemostatic effect of tranexamic acid mouthwash after oral surgery in patients also taking anticoagulants. The indication is that the anticoagulant need not be withdrawn prior to oral surgery if local antifibrinolytic therapy, such as tranexamic acid mouthwash, is instituted.

Health aspects, Surgery, Mouth, Stomatognathic system, Carboxylic acids

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Hemostatic drugs

Article Abstract:

Several hemostatic drugs are available to stop abnormal bleeding. Aminocaproic acid and tranexamic acid are both amino acids that inhibit the breakdown of blood clots. They are used to treat excessive menstruation, gastrointestinal bleeding, oral bleeding, and bleeding during surgery, including joint replacement and organ transplantation. Aprotinin also stabilizes blood clots and is used during surgery and organ transplantation. Desmopressin and conjugated estrogens are also used to stop bleeding.

Analysis, Hemostatics, Bleeding

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