A randomized, placebo-controlled study on the effect of cyclic intermittent etidronate therapy on the bone mineral density changes associated with six months of gonadotropin-releasing hormone agonist treatment

Article Abstract:

Etidronate therapy appears to prevent the bone mineral loss caused by gonadotropin-releasing hormone agonist (GnRH) treatment. GnRH suppresses estrogen and is used to treat endometriosis and uterine fibroid tumors. Researchers randomly assigned 31 menstruating women needing six months of treatment with GnRH to take oral etidronate or a placebo intermittently during treatment. Women taking the placebo experienced a 4% to 10% decrease in spinal bone density as well as altered bone mineralization metabolism as measured by blood and urine analysis. Women taking etidronate experienced neither of these changes.

Bones, Bone density, Gonadotropin releasing hormone, Gonadorelin, Etidronate disodium, Etidronate

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Progestogen therapy during pituitary desensitization with gonadotropin-releasing hormone agonist prevents functional ovarian cyst formation: a prospective, randomized study

Article Abstract:

Combining a progestogen with gonadotropin-releasing hormone appears to prevent ovarian cyst formation in women undergoing ovarian stimulation for in vitro fertilization. Women who received both hormones had fewer ovarian cysts and higher implantation and pregnancy rates.

Methods, Usage, Ovaries, Ovarian cysts, Progestational hormones, Fertilization in vitro, Human, Human fertilization in vitro

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A randomized, double-blind placebo-controlled trial of the effects of the 5-hydroxytriptamine(4) agonist cisapride on the female urinary bladder

Article Abstract:

The drug cisapride does not appear to affect the muscles that control the flow of urine from the bladder but it does decrease the amount of urine that the bladder can hold. Therefore, it may not be effective in treating urinary incontinence.

Urinary incontinence, Drug therapy, Cisapride

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