A randomized, placebo-controlled study on the effect of cyclic intermittent etidronate therapy on the bone mineral density changes associated with six months of gonadotropin-releasing hormone agonist treatment
Article Abstract:
Etidronate therapy appears to prevent the bone mineral loss caused by gonadotropin-releasing hormone agonist (GnRH) treatment. GnRH suppresses estrogen and is used to treat endometriosis and uterine fibroid tumors. Researchers randomly assigned 31 menstruating women needing six months of treatment with GnRH to take oral etidronate or a placebo intermittently during treatment. Women taking the placebo experienced a 4% to 10% decrease in spinal bone density as well as altered bone mineralization metabolism as measured by blood and urine analysis. Women taking etidronate experienced neither of these changes.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Progestogen therapy during pituitary desensitization with gonadotropin-releasing hormone agonist prevents functional ovarian cyst formation: a prospective, randomized study
Article Abstract:
Combining a progestogen with gonadotropin-releasing hormone appears to prevent ovarian cyst formation in women undergoing ovarian stimulation for in vitro fertilization. Women who received both hormones had fewer ovarian cysts and higher implantation and pregnancy rates.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A randomized, double-blind placebo-controlled trial of the effects of the 5-hydroxytriptamine(4) agonist cisapride on the female urinary bladder
Article Abstract:
The drug cisapride does not appear to affect the muscles that control the flow of urine from the bladder but it does decrease the amount of urine that the bladder can hold. Therefore, it may not be effective in treating urinary incontinence.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Spinal and peripheral bone mineral densities in acromegaly: the effects of excess growth hormone and hypogonadism
- Abstracts: Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients. Liver Enzyme Monitoring in Patients Treated With Troglitazone
- Abstracts: Predisposing factors for severe, uncontrolled hypertension in an inner-city minority population. Characteristics of patients with uncontrolled hypertension in the United States
- Abstracts: Regulation in a changing climate. Developing roles. Fit for practice: Legal issues in accountability
- Abstracts: Catheter confusion. A nurse-led service for tunnelled central venous catheter insertion. Review of catheter care guidelines