Alzheimer disease research in Japan: Public funding

Article Abstract:

The medical costs for Alzheimer disease treatment are estimated to be more than 50 billion yen per year and the total cost for care of demented individuals exceeds 2 trillion yen per year, therefore, there is a compelling need for treatment and prevention of Alzheimer disease and substantial funding for research in Japan. The major funding bodies are largely governmental, such as the Ministry of Education, Science, Sports and Technology (MEXT) and the Ministry of Health, Labor and Welfare (MHLW).

Science & research, Evaluation, Federal aid to research, Government aid to research

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Article Abstract:

Transgenic mice with Alzheimer presenilin 1 (PS-1) mutations have been shown to have accelerated neurodegeneration without amyloid plaque formation so the pathogenic role of the PS-1 mutation is upstream of the amyloid cascade. Careful quantitative studies on PS-1 transgenic mice were carried out. Without amyloid plaque formation, neurodegeneration was seen to be accelerated significantly in mice more than 13 months old and having familial Alzheimer disease mutant PS-1.

France, Hungary, Usage, Genetic aspects, Nervous system, Cytochemistry, Amyloid beta-protein, Genetically modified mice, Nerve degeneration

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Combating diabetes and obesity in Japan

Article Abstract:

The Japanese government is focusing on the development of means to reduce the cost of public medical services, which no more is able to contribute to the economic growth because of the increased aging rate. The government has launched many programs focusing on combating diseases like diabetes and obesity, as they have become very common due to the increasing urbanization and hence needs immediate attention and expensive treatments.

Government domestic functions, Prevention, Risk factors, Diabetes, Diabetes mellitus, Obesity, Wellness programs, Health policy

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