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Antiretroviral treatment simplification with 3 NRTIs or 2 NRTIs plus Nevirapine in HIV-1-infected patients treated with successful first-line HAART

Article Abstract:

An antiretroviral treatment simplification with coformulated zidovudine/lamivudine/abacavir (group 1) is compared with coformulated zidovudine/lamivudine plus nevirapine (group 2) in HIV-infected patients to assess its virologic noninferiority. It is concluded that group 1 is not inferior to group 2 regarding virologic suppression <200 copies/mL and both strategies improve lipid profile.

Author: Clotet, Bonaventura, Bonjoch, Anna, Paredes, Roger, Martinez, Eva, Galvez, Juan, Miralles, Celia, Videla, Sebastia, Miranda, Jose, Munoz-Moreno, Jose Antonio, Torre, Javier De la, Prieto, Arturo, Vilades, Consuelo
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
Care and treatment, HIV patients, Dosage and administration, Antiviral agents, Antiretroviral agents

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Lopinavir/Ritonavir plus nevirapine as a Nucleoside-sparing approach in antiretroviral-experienced patients (NEKA Study)

Article Abstract:

A study is made to compare the efficacy and safety of a nucleoside sparing approach with a conventional highly active antiretroviral therapy (HAART) regimen in antiretroviral-experienced patients with prolonged viral suppression. The result showed that all patients maintained viral suppression after 48 weeks and no subject discontinued therapy because of adverse events.

Author: Clotet, Bonaventura, Rey-Joly, Celestino, Negredo, Eugenia, Ruiz, Lidia, Burger, David, Martinez, Eva, Montaner, Julio, Miro, Oscar, Lopez, Sonia, Molto, Jose, Cote, Helene, Ribalta, Joseph, Puig, Jordi, Salazar, Juliana
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Nucleosides

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Treatment interruptions guided by CD4 counts and viral load

Article Abstract:

The rationale for treatment discontinuation in patients with undetectable or detectable plasma viral load was discussed. Successful treatment interruption was found to be associated with age (<35 years), high CD4 nadir, high pre-highly active antiretroviral therapy (HAART) CD4, and low pre-HAART viral load.

Author: Clotet, Bonaventura
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
Viremia, CD4 lymphocytes, Viral load

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Subjects list: Health aspects, United States, Highly active antiretroviral therapy, Research
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