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Oestrogen receptors in colorectal carcinoma

Article Abstract:

The association between breast cancer and colorectal cancer is clearly documented. The presence of similar epidemiological features suggests the possible existence of a common etiologic agent. Some investigators have reported the presence of estrogen receptors in up to 30 percent of colorectal carcinomas, but other researchers have been unable to demonstrate this relation. The current report reviews this discrepancy, and evaluates techniques for determining the presence of estrogen receptors in colorectal adenocarcinoma. Specifically, a ligand binding biochemical assay and two monoclonal antibody techniques, a quantitative enzyme immunoassay and an immunohistological staining method, are explored. Tumor tissue from 29 cases of adenocarcinoma of the colon and rectum were examined by the ligand binding assay. A weak estrogen receptor positive result was obtained in only one tumor. Eighteen tumors were examined by quantitative immunoassay and 13 by immunohistochemical methods; the results of both analyses were negative for estrogen receptors. These findings are consistent with previous reports of the absence of estrogen receptors in colorectal cancers, regardless of the sex of the patient. Furthermore, the data indicate that endocrine manipulations would be of little value in the treatment of these lesions. (Consumer Summary produced by Reliance Medical Information, Inc.)

Diagnosis, Testing, Colorectal cancer, Hormone receptors, Estrogen, Estrogen receptors

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Helicobacter pylori is not identified in areas of gastric metaplasia of gall bladder

Article Abstract:

Helicobacter pylori (H. pylori, previously known as Campylobacter pylori) has been identified in several types of gastric metaplasia (tissue that has been converted into an abnormal form) including duodenal, oesophageal and rectal. To determine if H. pylori is present in gastric metaplasia of the gall bladder, samples from 31 patients with gastric metaplasia were sectioned and stained with hematoxylin and eosin, and the Warthin-Starry technique was also used to allow visualization of H. pylori. H. pylori was not detected in any of the gall bladder tissue samples. It is suggested that the high concentration of bile in the gall bladder may prevent the growth of H. pylori in gastric metaplasia of the gall bladder. (Consumer Summary produced by Reliance Medical Information, Inc.)

Infection, Helicobacter pylori, Gallbladder, Gallbladder cancer, Metaplasia

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