Sickle cell anemia in adults: avoiding crises, organ damage
Now that half of all patients with sickle cell anemia are surviving well into their 40's, many internists need to be aware of the treatments for preventing the severe complications of this disease. The most common complications are the acute chest syndrome and painful crises. These are both probably caused by the accumulation of sickled red blood cells in arteries, which cuts off the blood supply to the region supplied by the artery. This can ultimately damage the lungs, liver and kidneys. Hydroxyurea and blood transfusions are two approaches that may limit such damage.
Publication Name: Annals of Internal Medicine
COX-2 inhibitors: Is there cause for concern?
Whether there is or is not cause for concern relative to the cyclooxygenase 2 (COX-2) inhibitors is discussed. A study has shown reasons for investigation into both risks and benefits to continue. The putative anti-inflammatory role of COX-2 and some prostaglandins may be in reality a pro-proliferative response of cells at the site of inflammation.
Publication Name: Nature Medicine
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