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Are all fats created equal?

Article Abstract:

Differential display of cDNAs is used to uncover the protein, Visafin that has similar biological actions as insulin is also supposed to impair insulin signaling leading to type 2 diabetes in humans. The results show that plasma visafin concentrations do not correlate with viscernal fat mass, as all adipocytes are not created equal due to the discrete hormone factories by different adipose depots.

Author: Bloom, Stephen R., Murphy, Kevin G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Article Abstract:

The replenishment of adiponectin, an adipocyte-derived hormone that provides a new treatment modality for insulin resistance and type 2 diabetes, is indicated. Adiponectin decreases insulin resistance by decreasing triglyceride content in muscle and liver in obese mice.

Author: Yamauchi, T ., Kamon, J., Waki, H., Terauchi Y., Kubota N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y ., Gavrilova, O., Vinson, C., Reitman M.L ., Kagechika, H., Shudo, K ., Yoda, M ., Nakano, Y., Tobe, K ., Nagai, R., Kimura, S., Tomita, M., Froguel, P ., Kadowaki, T.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Usage

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PGC-1 promoters insulin resistance in liver through PPAR-(alpha)-dependent induction of TRB-3

Article Abstract:

Reports indicating TRB-3 is a target for PPAR- (alpha) in liver are presented. Studies indicate link between nuclear hormone receptor and insulin signaling pathways and suggest the role of TRB-3 inhibitors in the treatment of type 2 diabetes.

Author: Evans, Ronald M., Herzig, Stephan, Olefsky, Jerrold, Seung-Hoi Koo, Hiroaki Satoh, Chih-Hao Lee, Susan Hedrick, Kulkarni, Rohit, Montminy, Mark
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Hormone receptors

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Subjects list: Care and treatment, Research, United States, Type 2 diabetes, Fat cells, Adipocytes
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