Association Between Minor Elevations of Creatine Kinase-MB Level and Mortality in Patients With Acute Coronary Syndromes Without ST-Segment Elevation

Article Abstract:

Even a small increase in blood levels of creatine kinase-MB (CK-MB) may be an indication that a patient is having a heart attack. This compound is released from heart muscle when it is damaged and can be measured in blood samples. Researchers measured blood levels of CK-MB in 8,250 patients who came to a hospital with the symptoms of a heart attack. None had ST-segment elevation on their ECG, which is also a sign of heart attack. Mortality rates at 30 days and 6 months were greater in those with elevated CK-MB levels, even if the increase was small.

Author: Alexander, John H., Sparapani, Rodney A., Mahaffey, Kenneth W., Deckers, Jaap W., Newby, L. Kristin, Ohman, E. Magnus, Corbalan, Ramon, Chierchia, Sergio L., Boland, Jean B., Simoons, Maarten L., Califf, Robert M., Topol, Eric J., Harrington, Robert A.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
Mortality, Heart attack, Creatine kinase

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Risk of Stroke Associated With Abciximab Among Patients Undergoing Percutaneous Coronary Intervention

Article Abstract:

The anticoagulant drug abciximab does not appear to increase the risk of stroke in patients who receive it to reduce their risk of forming dangerous blood clots during angioplasty. However, it should be used with low-dose heparin rather than standard-dose heparin to ensure that a blood clot will not form during the procedure.

Author: Deckers, Jaap W., Simoons, Maarten L., Califf, Robert M., Topol, Eric J., Lincoff, A. Michael, Boersma, Eric, Tcheng, James E., Akkerhuis, K. Martijn, Anderson, Keaven, Balog, Craig
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
Complications and side effects, Risk factors, Stroke (Disease), Stroke, Anticoagulants (Medicine), Anticoagulants

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Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes

Article Abstract:

The association between blood transfusion and mortality among patients with acute coronary syndromes who develop bleeding, anemia or both during their hospital course are determined. It was found that blood transfusion in the setting of acute coronary syndromes is associated with higher mortality and this relationship persists after adjustment for other predictive factors and timing of events.

Author: Newby, L. Kristin, Califf, Robert M., Topol, Eric J., Harrington, Robert A., Armstrong, Paul W., Granger, Christopher B., Stamler, Jonathan S., Moliterno, David J., Lindblad, Lauren, Rao, Sunil V., Pieper, Karen
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
Science & research, Research, Coronary heart disease, Blood transfusion

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Subjects list: Patient outcomes
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