Association between CCR5 genotype and the clinical course of HIV-1 infection
Article Abstract:
A genetic variation called heterozygosity for a 32-nucleotide deletion in the C-C chemokine receptor 5 gene (CCR5 delta 32) may slow disease progression in patients infected with the HIV-1 virus. The genes of 364 homosexual men with HIV were analyzed and they were followed using independent markers of disease progression. Those with the heterozygote variation showed significant delays in disease progression with slower decreases in T-lymphocytes and lower viral loads compared to men without the variation. A total of 48% of the long term survivors had this genetic variation, compared to 9% of those with progressive disease.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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CD4 cell counts of 800 cells/m[m.sup.3] or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/m[m.sup.3] or greater
Article Abstract:
The CD4 cell count changes are investigated in therapy-naive patients during 7 years of highly active antiretroviral therapy (HAART) in an observational cohort. It is concluded that restoration to CD4 cell counts mare than or equal to 800 cells/m[m.sup.3] is feasible within 7 years of HAART in most HIV patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
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Surrogate markers for disease progression in treated HIV infection
Article Abstract:
HIV-1 RNA levels and CD4+ T cell counts can be used as markers of disease progression in HIV patients. This was the conclusion of a study of 123 HIV-infected men.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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