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Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease

Article Abstract:

An enzyme in white blood cells called myeloperoxidase may cause atherosclerosis if present in increased quantities, according to a study of 158 patients with coronary artery disease and 175 healthy volunteers. The enzyme promotes the oxidation of fats, which is considered a risk factor for atherosclerosis.

Author: Topol, Eric J., Zhang, Renliang, Brennan, Marie-Luise, Fu, Xiaoming, Aviles, Ronnier J., Pearce, Gregory L., Penn, Marc S., Sprecher, Dennis L., Hazen, Stanley L.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
Causes of, Atherosclerosis, Lipid peroxidation

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Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy

Article Abstract:

Nitric oxide can oxidize proteins, which may be a risk factor for cardiovascular disease. This was the conclusion of a study of 100 patients with cardiovascular disease and 108 healthy people. This study also showed that a group of drugs called statins can decrease the amount of these oxidized proteins, in addition to lowering blood cholesterol levels. Nitric oxide is a natural substance in the body that relaxes blood vessels.

Author: Vita, Joseph A., Keaney, John F., Jr., Brennan, Marie-Luise, Fu, Xiaoming, Aviles, Ronnier J., Pearce, Gregory L., Penn, Marc S., Sprecher, Dennis L., Hazen, Stanley L., Shishehbor, Mehdi H., Goormastic, Marlene, Gokce, Noyan
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
Industrial Gas Manufacturing, Industrial gases, Nitric Oxide, Cardiovascular diseases, Complications and side effects

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Prognostic value of myeloperoxidase in patients with chest pain

Article Abstract:

The presence of an enzyme called myeloperoxidase in the blood may identify patients with chest pain who may be having a heart attack, according to a study of 604 patients. This blood test can be used in patients who have a negative troponin T test because myeloperoxidase can appear in the blood even if the heart is not damaged. Troponin T is another blood test used to diagnose a heart attack.

Author: Topol, Eric J., Nissen, Steven E., Brennan, Marie-Luise, Aviles, Ronnier J., Penn, Marc S., Hazen, Stanley L., Shishehbor, Mehdi H., Goormastic, Marlene, Lente, Frederick van, Nambi, Vijay, Pepoy, Michael L., McErlean, Ellen S.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Diagnosis, Heart attack

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Subjects list: Health aspects, Risk factors, Peroxidase
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