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Azodicarbonamide inhibits T-cell responses in vitro and in vivo

Article Abstract:

The drug azodicarbonamide inhibits CD4 T cells and may be useful in treating inflammatory diseases and autoimmune disorders. Mice with a skin allograft that received the drug had delayed graft rejection. The drug also has anti-HIV activity.

Author: Goldman, Michel, Leo, Oberdan, Tassignon, Joel, Ismaili, Jamila, Le Moine, Alain, Laethem, Francois, Vandevelde, Michel
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Research, Immunosuppressive agents

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Gene expression profiles of laser-captured adjacent neuronal subtypes

Article Abstract:

The authors discuss the methods of displaying microarrays of genes to observe forms of expression. They explain a technique whereby additional information can be gathered by adding in the use of laser capture microdissection.

Author: Luo, Lin, Jackson, Michael R., Salunga, Ranelle C., Guo, Hongqing, Bittner, Anton, Joy, K.C., Galindo, Jose E., Xioa, Huinian, Rogers, Kathryn E., Wan, Jackson S., Erlander, Mark G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999

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The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

Article Abstract:

The DNA-binding protein PEA3 downregulates the HER-2/neu promoter gene, which is overexpressed in some tumors. This technique could be used in other diseases characterized by overexpression of certain genes.

Author: Xing, Xiangming, Wang, Shao-Chun, Xia, Weiya, Zou, Yiyu, Shao, Ruping, Kwong, Ka Yin, Yu, Zhenming, Zhang, Su, Miller, Susan, Huang, Leaf, Hung, Mien-Chie
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Prevention, Carcinogenesis

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Subjects list: Physiological aspects, Gene expression
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