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CYP2C19 genotype does not represent a genetic predisposition in idiopathic systemic lupus erythematosus

Article Abstract:

The CYP2C19 gene type does not appear to increase the risk of developing systemic lupus erythematosus (SLE), an autoimmune connective tissue disorder. The particular gene type, associated with cytochrome P450, reduces the ability of the body to metabolize certain drugs. SLE sometimes develops after exposure to particular drugs or chemicals. Researchers gave the drug mephenytoin to 37 SLE patients and 161 healthy people, then measured drug metabolites in their urine. Genetic examination of blood samples indicated that the CYP2C19 gene type was not more common among SLE patients, and the ratio of drug metabolites in the urine samples failed to show an association between the gene type and SLE.

Denmark, Turkey, Health aspects, Genetic aspects, Systemic lupus erythematosus, Genetic polymorphisms

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Paradoxical effect of prostacyclin infusion in a patient with primary pulmonary hypertension: A case report

Article Abstract:

The paradoxical effect of prostacyclin treatment in a patient with primary pulmonary hypertension is presented by a case report. This case report shows an increase in pulmonary artery pressure in the patient when treated with prostacyclin infusion.

United States, Care and treatment, Case studies, Evaluation, Pulmonary hypertension, Prostacyclin

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