Abstracts

Health

Search abstracts:

Characterization of large-conductance, calcium-activated potassium channels from human myometrium

Article Abstract:

The muscular wall of the uterus (myometrium) may have two types of potassium channels. These channels may cause the potassium currents involved in the initiation of uterine contractions. A study examined the different types of potassium channels in myometrium samples from premenopausal women who were not pregnant. The most common type of potassium channel was a 'maxi' calcium-activated potassium channel. This type of channel was sensitive to intracellular calcium and had a large conductance. It was similar to calcium-activated potassium channels found in other types of tissue and in other species. Several different types of drugs affected the activity of this type of channel. Another less common type of potassium channel was also found in the samples of myometrium. This channel was less sensitive to intracellular calcium and had lower conductance.

Measurement

---

Expression of different potassium channels in cells isolated from human myometrium and leiomyomas

Article Abstract:

The electrical properties of myometrial and leiomyoma cells may be different. The myometrium is the smooth muscle coat of the uterus. A leiomyoma is a benign tumor derived from the myometrium. A study examined the different types of potassium channel currents in myometrial and leiomyoma cells. Three types of potassium channel currents were found in myometrial cells. These included two types of noninactivating outward currents and one type of inactivating current. Leiomyoma cells were more likely to have fast outward inactivating potassium channel currents. Different types of complications caused by leiomyomas include infertility and abnormal uterine bleeding.

---

The expression of integrins and cadherins in normal human uterus and uterine leiomyomas

Article Abstract:

Two molecules responsible for cell adhesion called cadherin and integrin seem to be expressed in a similar pattern in normal uterine tissue and in leiomyomas. Leiomyomas are a common nonmalignant uterine tumor. Researchers compared cadherin and integrin patterns in tissue samples taken from normal uterine lining, normal uterine muscle, and leiomyoma. Cadherin and integrin patterns were similar in all tissue samples. These patterns changed in the uterine lining cells during the menstrual cycle but remained constant in the uterine muscle and leiomyoma cells.

Cell adhesion molecules

Similar abstracts:

• Abstracts: Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Longitudinal evaluation of markers of endothelial cell dysfunction and hemostasis in treated antiphospholipid syndrome and in healthy pregnancy
• Abstracts: Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event
• Abstracts: Trends in HIV prevalence among disadvantaged youth: survey results from a national job training program, 1988 through 1992
• Abstracts: Boosting practice activity and patient service. Providing oral care for the aging patient. Why switch to digital radiography?
• Abstracts: Corticotropin-releasing factor and its binding protein: maternal serum levels in term and preterm deliveries. Association between pregnancy-induced hypertension and asthma during pregnancy

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.