Organotypic raft cultures for the in vitro evaluation of vaginal microbicidal agents

Article Abstract:

Some chemicals frequently used in contraception products may cause damage to genital skin cells. Cervical cells carrying genes for the papilloma virus and foreskin cells were treated with chlorhexidine, nonoxinol 9, benzalkonium chloride, and cholic acid. The chemicals were added either while the cells were below the medium's surface or floating at the medium's surface. Cell damage as measured by interleukin-6 levels was evident in the floating cells but not in the submerged cells.

Complications and side effects, Anti-infective agents, Epithelial cells

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Glutathione S-transferase M1 genotypes and the risk of vulvar cancer: a population-based case-control study

Article Abstract:

The impact of having the glutathione S-transferase M1 null genotype and the risk of vulvar cancer in women is described. The genetic polymorphism is common but does not increase the odds of developing vulvar cancer.

Research, Physiological aspects, Genetic aspects, Genetic polymorphisms, Glutathione transferase, Vulvar cancer

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