Cross-clade CD8 T-cell responses to HIV(sub IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors

Article Abstract:

T-cell cytokine production and cytotoxicity against uniform populations of HIV-infested primary cells were measured to quantify the extent of cross-clade reactivity within the CD8 T-cell response to viral antigens on infected primary cells. Analysis of IFN-gamma production and cytotoxicity by CD8 T-cells from North American and Chinese HIV-infected donors revealed no significant differences in responses to clade B (IIIB) virus compared to representative Chinese B' and C/W viruses.

HIV infection, HIV infections, Genetic aspects, T cells

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RNA interference targeting Fas protects mice from fulminant hepatitis

Article Abstract:

Injecting agonistic Fas-specific antibody induces fulminant hepatitis in mice, 82% of which treated with small interfering RNA to silence Fas survived for 10 days. Results suggest that the Fas small interfering RNA reduces Fas mRNA levels and expression of Fas protein in mouse hepatocytes, which are resisant to apoptosis.

China, Physiological aspects, Drug therapy, Gene expression, RNA, Hepatitis B, Viral genetics, Viral antibodies, Antibodies

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The prospect of silencing disease using RNA interference

Article Abstract:

RNA interference (RNAi) is an endogenous cellular gene silencing mechanism, whose discovery has provided a powerful tool for basic science researchers to study gene function. The basic mechanism of RNAi, the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease are discussed.

Gene silencing, RNA interference

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