Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand apo2L/TRAIL
Article Abstract:
A new mechanism is described that has modulated Apo2 ligand (also known as tumor necrosis factor-related apoptosis-inducing ligand and referred to as Apo2L/TRAIL) signaling in tumors through death-receptor O-glycosylation. The results have revealed a new link between death-receptor O-glycosylation and apoptotic signaling, thus providing predictive biomarkers for Apo2L/TRAIL-based cancer therapy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells
Article Abstract:
A demonstration that hypoxia inducible factor (HIF-1) alpha deficiency in colon cancer cells could inhibit proliferation and overall growth, but no angiogenesis is presented. Among human tumors, overexpression of HIF-1 alpha is associated with improved survival in individuals with head and neck cancers and HIF-1 could inhibit the growth of renal carcinoma cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Calreticulin exposure dictates the immunogenicity of cancer cell death
Article Abstract:
Athracyclins induce the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and it is mimicked by inhibition of the protein phosphate 1/GADD34 complex. Results indicate CRT to be a key feature in determining anticancer immune responses and describe a possible strategy for immunogenic chemotherapy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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