Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand apo2L/TRAIL

Article Abstract:

A new mechanism is described that has modulated Apo2 ligand (also known as tumor necrosis factor-related apoptosis-inducing ligand and referred to as Apo2L/TRAIL) signaling in tumors through death-receptor O-glycosylation. The results have revealed a new link between death-receptor O-glycosylation and apoptotic signaling, thus providing predictive biomarkers for Apo2L/TRAIL-based cancer therapy.

Health aspects, Glycosylation, Tumor necrosis factor, Tumour necrosis factor

---

Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells

Article Abstract:

A demonstration that hypoxia inducible factor (HIF-1) alpha deficiency in colon cancer cells could inhibit proliferation and overall growth, but no angiogenesis is presented. Among human tumors, overexpression of HIF-1 alpha is associated with improved survival in individuals with head and neck cancers and HIF-1 could inhibit the growth of renal carcinoma cells.

United States, Interleukin-8, Angiogenin, Colon cancer

---

Calreticulin exposure dictates the immunogenicity of cancer cell death

Article Abstract:

Athracyclins induce the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and it is mimicked by inhibition of the protein phosphate 1/GADD34 complex. Results indicate CRT to be a key feature in determining anticancer immune responses and describe a possible strategy for immunogenic chemotherapy.

Causes of, Cell death, Immunogenetics

Similar abstracts:

• Abstracts: Adherence to antiretroviral medication among HIV-positive patients in Thailand. Safety and antiretroviral effectiveness of concomitant use of rifampicin and efavirenz for antiretroviral-naive patients in India who are co infected with tuberculosis and HIV-1
• Abstracts: Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
• Abstracts: Conservative conization for microinvasive carcinoma of the cervix. Congenital chylothorax in three siblings
• Abstracts: Risk factors for neonatal mortality among extremely-low-birth-weight infants. Five years to the term breech trial: The rise and fall of a randomized controlled trial
• Abstracts: Analysis of indications for referral to a multidisciplinary medical genetics clinic: implications for training programs in obstetrics and gynecology

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.