Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy
Article Abstract:
Rearrangement of the collagen fibers within joint tissue subject ot heavy use may predispose patients to future disease or injury. Collagen is a protein found in the fibers of connective tissues. Using quantitative polarized light microscopy, researchers examined joint tissue samples from 20 beagle dogs who had run 40 kilometers per day on a treadmill over a 15 week period (study group) or who had not exercised (controls). There was significant collagen reorientation in the outer joint tissue layers of the shin, upper back leg, and upper front leg of the study group. There was a slight collagen volume decrease in the outer tissue layer of the outside upper back leg joint. The width of these fibers did not change at this site. The collagen concentrations from the upper front leg joint were similar for both sample sets. There was not any significant difference in reorientation in the deeper tissue layers. The overall physical appearance of both sample sets was similar.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Immobilisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage
Article Abstract:
It may take a long time for cartilage to recover following a period of prolonged immobilization. Researchers measured one aspect of cartilage physiology, proteoglycan concentration and synthesis, in the knee joints of young dogs after 11 weeks of knee immobilization. Fifty weeks after the knee was remobilized, proteoglycan levels had not returned to normal. On the other hand, proteoglycan levels increased in the other knee, which had not been immobilized.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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