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Diagnostic value of blood sampling in fetuses with growth retardation

Article Abstract:

Fetal-blood sampling may be an effective method for monitoring fetuses with intrauterine growth retardation. This type of sampling involves measurement of the oxygen content, hemoglobin and lactate concentrations, blood gas levels and pH of fetal blood. Among 56 fetuses suffering from intrauterine growth retardation, 21 fetuses had a normal heart rate and blood flow, 24 had a normal heart rate and abnormal blood flow and 11 had an abnormal heart rate and blood flow. None of the fetuses with a normal heart rate and blood flow had low blood levels of oxygen or low blood pH. Seventeen percent of the fetuses with a normal heart rate and abnormal blood flow had lactic acidosis, 4% had low blood pH and 12% had low blood levels of oxygen. Sixty-four percent of the fetuses with an abnormal heart rate and blood flow had lactic acidosis, low blood levels of oxygen and low blood pH.

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Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies

Article Abstract:

Women with growth-restricted pregnancies may experience significantly increased plasma amino acid concentrations as compared to those of women with healthy pregnancies. Researchers analyzed various amino acid concentrations in the plasma of five nonpregnant women, 21 women with appropriate-for-gestational-age fetuses, and 23 women with growth-restricted pregnancies. Women with normally growing fetuses showed significant reductions in plasma concentrations of most amino acids compared to nonpregnant women. In contrast, women with intrauterine-growth-restricted (IUGR) pregnancies had much higher levels of nine amino acids than women with normal pregnancies. Alpha-amino nitrogen levels were much higher in IUGR pregnancies. A deficiency in the mother's ability to adapt amino acid levels during pregnancy may indicate or lead to IUGR.

Amino acid metabolism

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Umbilical amino acid uptake at increasing maternal amino acid concentrations: effect of a maternal amino acid infusate

Article Abstract:

Amino acids taken by a pregnant woman are able to cross the placenta and nourish the fetus. This was confirmed by researchers who measured amino acid levels in the umbilical cords after the mother drank an amino acid solution just before a cesarean delivery.

Measurement, Maternal-fetal exchange, Amino acids, Umbilical arteries

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