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Directly observed therapy for treatment completion of pulmonary tuberculosis: consensus statement of the Public Health Tuberculosis Guidelines panel

Article Abstract:

Directly observed therapy (DOT) appears to be the most effective treatment for tuberculosis, especially when it includes social services to help the patient comply with treatment. DOT means that a health care worker or social worker observes the patient take the medication. Researchers evaluated 27 studies of various treatment regimens for tuberculosis, 12 of which used DOT. The DOT studies reported treatment completion rates from 86% to 96%, whereas studies that did not use DOT reported treatment completion rates of 42% to 82%. DOT programs often give patients reminders, food and transportation to ensure compliance.

Drug therapy, Tuberculosis

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Vaccine against human hepatitis B

Article Abstract:

The editors of JAMA reprint one of the first articles reporting the development and testing of a vaccine against hepatitis B. Viral antigens were purified from blood samples from infected patients. The experimental vaccine was tested in chimpanzees, guinea pigs and marmosets. All these animal groups produced antibodies against the virus after vaccination with the antigens. Three doses of the vaccine completely protected chimpanzees from infection with human hepatitis virus.

Research, Testing, Hepatitis viruses

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Association Between Administration of Hepatitis B Vaccine at Birth and Completion of the Hepatitis B and 4:3:1:3 Vaccine Series

Article Abstract:

Children are more likely to receive all three doses of hepatitis B vaccine if they receive the first dose shortly after birth. The American Academy of Pediatrics recommends giving the first dose before the baby is discharged from the hospital, the second at 1 to 2 months of age, and the third by 6 to 18 months of age.

Children, Vaccination of children, Vaccination, Dosage and administration

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