Abstracts » Health

Pre-eclampsia and induction of labor: a randomized comparison of prostaglandin E2 as an intracervical gel, with oxytocin immediately, or as a sustained-release vaginal insert

Article Abstract:

Prostaglandin E2 intracervical gel, followed immediately by intravenous oxytocin, appears to be more effective than a prostaglandin vaginal insert in inducing obstetrical labor in women with preeclampsia. Preeclampsia is a hypertensive complication of pregnancy that can cause fetal injury, so labor may be medically stimulateds. Researchers compared Prepidil, a prostaglandin gel, and Cervidil, a vaginal insert, in the treatment of 70 preeclamptic patients. Prepidil treatment induced vaginal delivery in an average of 11.5 hours, while Cervidil induced delivery in an average of 25.8 hours.

Drug therapy, Preeclampsia, Synthetic prostaglandins E

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Effectiveness of prostaglandin E2 intracervical gel (Prepidil), with immediate oxytocin, versus vaginal insert (Cervidil) for induction of labor

Article Abstract:

Prostaglandin E2 as an intracervical gel, when used with oxytocin, may more rapidly and less expensively induce labor, compared to a prostaglandin vaginal insert. Researchers compared Prepidil gel and the Cervidil insert for inducing labor in pregnant women with resistant cervices. The gel induced labor leading to delivery in an average of 11 hours, compared to 25 hours in patients given the vaginal insert. Treatment with the gel form of the drug was $458 less expensive than the insert.

Prostaglandins E

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