Eating bone or adding it: The Wnt pathway decides
Article Abstract:
Researchers have shown that blocking the activity of Dickkopf-1 (DKK-1), an inhibitor of the wingless (Wnt) signaling pathway, has revered the bone destruction in joints in mouse models of inflammatory arthritis. The results have implicated the Wnt pathway in controlling the pattern of both bone formation and resorption in human joint disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model
Article Abstract:
AIDS-associated Kaposi's sarcoma (AIDS-KS) cells have been found to express surface interleukin-4 (IL-4) receptors in a study using nude mice. IL-4 toxin (IL-4(38-37)-PE38KDEL) is specifically toxic to the cells. Metabolic changes brought on by KS tumors were prevented by IL-4 toxin treatment. These included lymphopenia and cachexia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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