Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: Results from ACTG 384
A detailed analysis of the changes in naive and memory CD4 cell subsets, natural killer and B cells, and T-cell activation after starting antiretroviral medication were studied to evaluate the effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy (ART) in antiretroviral-naive HIV-1-infected patients. The finding suggests that ART leads to reconstitution of CD4 cells capable of responding to new antigens, which is consistent with the clinical improvement in most subjects who receive treatment.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Antiretroviral Drug Resistance Testing in Adults With HIV Infection, Part 4
Genetic testing of the virus in HIV-infected patients may be useful in guiding antiviral drug therapy to maximize effectiveness and reduce development of drug resistance. A panel of experts assembled by the International AIDS Society - USA recommends viral load and CD4+ T-cell count as immunologic guides for antiretroviral drug therapy. Poor patient compliance with treatment protocols contributes to the development of drug-resistant HIV. Resistance testing may be useful for determining the optimal drugs for use in treatment.
Publication Name: JAMA, The Journal of the American Medical Association
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