Milk- and soy-protein ingestion: acute effect on serum uric acid concentration
Epidemiological studies show that blood levels of uric acid may be related to the development of coronary heart disease, or disease of the major blood vessels supplying the heart; hypertension, or high blood pressure; insulin resistance; and risk of death. Hence, it has been suggested that a decrease in uricemia, the presence of uric acid in the blood, may be beneficial for some groups of people. Uric acid in the blood results from dietary sources and from the body's production of uric acid, and is eliminated from the body by the kidneys. Increased protein, fat, and nucleic acid intake may worsen hyperuricemia, or abnormally high levels of uric acid in the blood. Protein intake increases the elimination of uric acid, but its effect on blood levels of uric acid are not clear. The effects of three types of proteins (casein, lactalbumin, and soybean isolate) on blood levels of uric acid and urinary excretion of uric acid were assessed in 10 healthy subjects. The blood and urine levels of uric acid were measured before and after ingesting 80 grams of each of the three proteins. Blood uric acid levels were decreased by casein and lactalbumin but increased by soybean within three hours. All proteins increased the urinary excretion of uric acid. These findings are consistent with the ability of these proteins to increase uric acid excretion. In addition, the results show that casein and lactalbumin, which are proteins contained in milk, can decrease blood uric acid levels. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: American Journal of Clinical Nutrition
The neglected organ: bacterial flora has a crucial immunostimulatory role
Research determined the importance of lipopolysaccharides (LPS) in ensuring eukaryotic survival. LPS are major components of gram-negative bacterial cell membranes, primarily absorbed in the gut and composed of heteropolysaccharide chains, the most active part of which is the membrane-associated lipid A. They mediate immunological reactions by activating the synthesis of macrophages, leukocytes, prostaglandins and cytokines which, in turn, prevents infections and inhibits the growth of neoplasms.
Publication Name: Perspectives in Biology and Medicine
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