Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection

Article Abstract:

The effect of highly active antiretroviral therapy (HAART) on the natural history of anal squamous intraepithelial lesions (ASIL) - the likely anal cancer precursor - and anal human papillomavirus (HPV) infection has been studied. Results show that HAART has only a small effect on ASIL or HPV in the first 6 months after HAART is started. The men who had sex with men (MSM) in the study had been followed in a cohort study for several years before HAART became available so it was possible to compare the natural history before and after HAART initiation. AIDS is a risk factor for anal HPV infection and ASILs in men.

United States, Research, Evaluation, Drug therapy, Papillomavirus infections, Precancerous conditions, AIDS (Disease), AIDS research, Epithelium, Highly active antiretroviral therapy

---

Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors

Article Abstract:

HIV-positive homosexual men may be at higher risk than HIV-negative men of developing cellular changes in the anus that could lead to anal cancer. Researchers examined 346 HIV-positive and 262 HIV-negative homosexual and bisexual men for evidence of anal squamous intraepithelial lesions (ASIL). ASIL was detected in 36% of men with HIV and 7% of men without HIV infection. Anal infection with human papillomavirus and a history of receptive anal intercourse increased the risk of ASIL, regardless of HIV status. Screening of homosexual men for ASIL may prevent anal cancer.

---

Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men

Article Abstract:

HIV-positive homosexual men may be at higher risk for anal squamous intraepithelial lesions (ASIL) and possibly for anal cancer than HIV-negative homosexual men. ASIL are cellular changes that may develop into cancer. Researchers examined 346 HIV-positive and 262 HIV-negative homosexual men for evidence of anal diseases. Twenty percent of HIV-positive men developed high-grade intraepithelial lesions, compared to 8% of HIV-negative men, during the two years they were studied. Infection with human papillomavirus increased the risk of ASIL, regardless of HIV status.

HIV patients, Epithelial tumors

Similar abstracts:

• Abstracts: Effect of antiretroviral therapy on the incidence of genital warts and vulvar neoplasia among women with the human immunodeficiency virus
• Abstracts: Highly Active Antiretroviral Therapy in a Large Urban Clinic: Risk Factors for Virologic Failure and Adverse Drug Reactions
• Abstracts: The Clinical Effectiveness and Cost-effectiveness of Screening for Anal Squamous Intraepithelial Lesions in Homosexual and Bisexual HIV-Positive Men
• Abstracts: Effects of cigarette smoking on lung function in adolescent boys and girls. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead
• Abstracts: The use of central venous catheters for IV therapy. Central venous catheters: Some common clinical questions. Managing occlusion in central venous catheters

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.