Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy

Article Abstract:

Research presented concerns the dynamics of HIV infection after the use of highly active anti-retroviral therapy by HIV patients. Topics addressed include how the latent viral reservoir affects CD4 T cells and rebounding plasma viremia.

Author: Chun, Tae-Wook, Davey, Richard T. Jr., Ostrowski, Mario, Justement, J. Shawn, Engel, Delphine, Mullins, James I., Fauci, Anthony S.
Viremia, CD4 lymphocytes

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Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes

Article Abstract:

A model of HIV virus progression in rhesus monkeys is presented, focusing on the difficulties of achieving an antibody or immunological response to HIV-1 envelope proteins. Rhesus macaques were immunized with phage-displayed epitopes and evaluated for protection levels from viral challenge.

Author: Lewis, Mark G., Chun, Tae-Wook, Justement, J. Shawn, Fauci, Anthony S., Venzon, David, Chen, Xueni, Scala, Giuseppe, Quinto, Ileana, Liu, Weimin, Cohen, Oren J., VanCott, Tom C., Iwanicki, Marcin, Greenhouse, Jack, Barry, Todd
Italy, Statistical Data Included, Diseases, AIDS vaccines, Rhesus monkey

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Effect of interleukin-2 on the pool of latently infected, resting CD4(super.+) T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

Article Abstract:

Intermittent administration of interleukin (IL)-2 with continuous highly active anti-retroviral therapy (HAART) may lead to a substantial reduction in the pool of resting CD4(super.+) T cells containing replication-competent HIV. In a recent study it was found that virus could not be isolated from the peripheral blood CD4(super.+) T cells in three patients receiving IL-2 plus HAART. The size of the pool of resting CD4(super.+) T cells containing replication-competent HIV in the blood of patients receiving intermittent IL-2 plus HAART was significantly lower than that of patients getting only HAART.

Author: Corey, Lawrence, Kovacs, Joseph A., Lane, H. Clifford, Chun, Tae-Wook, Engel, Delphine, Fauci, Anthony S., Davey, Richard T., Jr., Metcalf, Julia A., Park, Sohee, Hallahan, Claire W., Dybul, Mark, Mizell, Stehanie B., Fishette, Maria, Mican, JoAnn M., Berrey, M. Michelle
Health aspects, Drug therapy, Interleukin-2

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Subjects list: Research, United States, HIV infection, HIV infections, Highly active antiretroviral therapy, Physiological aspects, HIV (Viruses), HIV
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