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Effects of recombinant leptin therapy in a child with congenital leptin deficiency

Article Abstract:

Leptin treatment may be beneficial for obese children. Leptin is a hormone involved in regulating body weight. Researchers treated a 9-year-old girl with leptin deficiency with daily injections of recombinant leptin. At the beginning of therapy, she weighed 207 pounds. During the one-year treatment, she lost about 36 pounds at the rate of 2 to 4 pounds per month. Her fat mass dropped considerably but her lean body mass increased. Her basal metabolic rate also decreased 18%, but she became more physically active. Her body produced antibodies against the injected leptin but the antibodies did not seem to change the effectiveness of the treatment.

Health aspects, Care and treatment, Leptin

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Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

Article Abstract:

A mutation in the gene for the melanocortin 4 receptor appears to be one cause of obesity, according to a study of 500 obese children. This gene codes for the receptor for an enzyme called alpha melanocyte-stimulating hormone. The hormone causes a decrease in food consumption. The mutation would create a defective receptor, which could interfere with the proper function of the hormone.

Intermedin, Melanocyte stimulating hormone

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Melanocortin receptors weigh in

Article Abstract:

The melanocortin-4 receptor (MC4R) that is highly expressed in the brain acts as a central regulator of food intake and fat mass. The studies confirming the MC4R links to obesity is presented.

United States, Science & research, Biological Product (except Diagnostic) Manufacturing, Drugs, Biological Processors, Bioreactors, Research, Gene mutations, Gene mutation, Obesity

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