The 3' untranslated region of messenger RNA: a molecular 'hotspot' for pathology?

Article Abstract:

Research of the 3' untranslated region, or 3' UTR, of messenger RNA is presented. Issues discussed include gene and mRNA expression, the ways in which diseases such as myontonic dystrophy may arise from the region, and related functional disturbances in cells.

Messenger RNA, Pathology, Myotonic dystrophy

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Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells

Article Abstract:

Research presented indicates that transfer of retrovirus-mediated genes into hematopoietic stem cells and into progenitor cells can be achieved. Methods involve co-localizing target cells and retroviral particles on fibronectin specific adhesion domains; and transfering of human multi-drug resistant genes into stem and progenitor cells.

Stem cells, Retroviruses, Drug resistance, Hematopoietic agents, Blood transfusion, Autologous, Autologous blood transfusion

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Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy

Article Abstract:

Research has been conducted on the bone-marrow transplantation of beta-galactosidase-expressing cells into the aortic allograft recipients. The results indicate that the intimal cells include those of the marrow origin and that the smooth-muscle-like cells in graft arterial disease lesions can originate from the circulating bone-marrow-derived precursors.

Statistical Data Included, Abnormalities, Bone marrow, Smooth muscle, Aorta

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