Embryonic and tumorigenic pathways converge via nodal signaling: Role in melanoma aggressiveness
Article Abstract:
The cellular interactions between human melanoma cells and embryonic progenitor cells using the zebrafish embryo as a model was identified to show that aggressive melanoma cells induce the formation of ectopic embryonic axes and that Nodal, a potent embryonic morphogen from the transforming growth factor (TGF)-[beta] family is a key regulator of melanoma tumorigenicity. The findings of the study highlight the convergence of tumorigenic and embryonic signaling pathways and implicate Nodal as a diagnostic marker of disease progression and a target for the treatment of aggressive cancers such s melanomas.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Cracking the cytokine code in psoriasis
Article Abstract:
Mouse models of cutaneous inflammation are used to show that interleukin (IL)-23 play a vital role in psoriasis. Psoriatic lesions in humans have distinctive clinical, histological and immunopathological features and the pathways by which the IL-23- and [T.sub.H]17 (T-helper type 17)-mediated inflammation is terminated should be considered while determining psoriasis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
Article Abstract:
The characterization of epidermal keratinocytes and psoriatic lesions by activated Stat3 (K5.Stat3C mice) is reported. It was found that transgenic mice with keratinocytes expressing a constitutively active Stat3 develop a skin phenotype either spontaneously, or in response to wounding, that closely resembles psoriasis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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