Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding

Article Abstract:

Drug treatment with the beta blocker nadolol and isosorbide mononitrate appears to be more effective than endoscopic ligation for treating esophageal bleeding from varices. Varices are enlarged blood vessels that can bleed repeatedly despite treatment.

Isosorbide mononitrate

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Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding

Article Abstract:

The beta blocker nadolol in conjunction with isosorbide mononitrate appears to be more effective than sclerotherapy in preventing rebleeding from esophageal varices. Varices are abnormally large veins that bleed easily. Eighty-six patients with bleeding esophageal varices were randomly allocated to receive sclerotherapy or nadolol and isosorbide mononitrate. Twice as many patients receiving sclerotherapy had an episode of rebleeding. Nadolol and isosorbide mononitrate were more effective at reducing pressure in the liver and patients with reduced pressure were much less likely to rebleed.

Injuries, Vasodilators, Vasodilator agents

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Comparison of endoscopic ligation and propanolol for the primary prevention of variceal bleeding

Article Abstract:

Endoscopic ligation appears to be more effective than propanolol in the treatment of esophageal varices. Esophageal varices are dilated veins in the esophagus that can begin bleeding. They often occur in people with liver cirrhosis. Researchers randomly assigned 89 patients, 82 of whom had cirrhosis, to take propanolol or receive endoscopic ligation. During this procedure, small rubber bands are placed around the vein. The risk of bleeding 18 months later was 43% in those who took propanolol and 15% in those who received endoscopic ligation.

Propranolol hydrochloride, Propranolol

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