Endothelial signaling during development
Article Abstract:
The importance of investigating basic vascular biology is underlined by the emerging likelihood that paracrine endothelial cues have a role in tissue differentiation and organ formation. The nature of this signaling and its heterogeneity could lead to novel targeted therapeutic approaches for a variety of diseases such as heart disease, diabetes or cancer is examined.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects
Article Abstract:
A superoxide dismutase (SOD) mimetic, M40403 blocked IL-2-induced hypotension and allowed the dose of IL-2 to be increased in mice. It was established that M40403 prevented Il-2 form causing dose-limiting hypotension, while enhancing its anticancer activity.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
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