Ethanol stimulation of HIV infection of oral epithelial cells
The HIV strain, NL4-3 was modified by inserting the enhanced green fluorescent protein gene and the virus was used to infect oral epithelial cells obtained from patients and various concentrations of ethanol were added to the infected cells. It was learnt that ethanol significantly increased HIV infection of primary oral epithelial cells.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection
The successful targeting in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope is described. Further development in the targeted gene transduction might result in applications not only for cancers but also for genetic, infectious and immune diseases.
Publication Name: Nature Medicine
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