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Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous keukemia

Article Abstract:

Results demonstrate that chronic myelogenous leukemia patients with bone marrow transplant or interferon-alpha2b or chemotherapy treatment, develop a proteinase 3-derived peptide PR1 suggesting that T lymphocytes conferred immunity is involved in the removal of malignant cells.

Author: Molldrem, Jeffrey J., Lee, Peter P., Wang, Changqing, Fello, Kyrie, Kantarijan, Hagop M., Champlin, Richard E., Davis, Mark M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Statistical Data Included, Analysis, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Immune response, Chronic myeloid leukemia

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Ex vivo identification, isolation and analysis of tumor-cytolytic T cells

Article Abstract:

Research demonstrates isolation of tumor-cytolytic T cells directly from patient blood samples following cancer vaccination. Direct correlation between antigen specificity and cytolytic activity, at a single-cell level, is made by surface mobilization coupled with peptide-major histocompatibility complex tetramer staining. Expansion of tumor-cytolytic T cells ex vivo is presented.

Author: Lee, Peter P., Betts, Michael R., Roederer, Mario, Rubio, Valerie, Stuge, Tor B., Singh, Naileshni, Weber, Jeffrey S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Science & research, Research, Methods, Cancer research, Tumors, Immunotherapy, Tumours

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Characterization of circulating T cells specific for tumor-associated antigens in melonoma patients

Article Abstract:

Circulating T cells specific for tumor-associated antigens (TAAs) in melanoma patients have been characterized. Circulating CD8(super.+) T-cell populations specific for the TAAs MART-1 (27-35) or tyrosinase (368-376) have been identified in six of eleven patients with metastatic melanoma using peptide/HLA-A(super.*)0201 tetramers.

Author: Johnson, Denise, Lee, Peter P., Davis, Mark M., Roederer, Mario, Thompson, John, Greenberg, Philip D., Yee, Cassian, Weber, Jeffrey S., Brockstedt, Dirk, Savaga, Peter A., Fong, Lawrence, Swetter, Susan
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Melanoma

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Subjects list: United States, Physiological aspects, Cancer, T cells
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