Standard Short-Course Chemotherapy for Drug-Resistant Tuberculosis: Treatment Outcomes in 6 Countries

Article Abstract:

People with drug-resistant tuberculosis will be harder to treat than those with susceptible strains of the tuberculosis bacterium. This was the conclusion of a study of 6,402 tuberculosis patients. Twenty-one percent of the new cases and 44% of the re-treatment cases were had strains that were resistant to at least one TB drug. Treatment failures and mortality rates were higher among those with resistant strains. This was true even in patients who received directly observed treatment (DOT).

Author: Espinal, Marcos A., Kim, Sang Jae, Suarez, Pedro G., Kam, Kai Man, Khomenko, Alexander G., Migliori, Giovanni B., Baez, Janette, Kochi, Arata, Dye, Christopher, Raviglione, Mario C.
Health aspects, Drug therapy

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Global trends in resistance to antituberculosis drugs

Article Abstract:

Many countries have high rates of drug resistant tuberculosis, according to a survey conducted by the World Health Organization and the International Union against Tuberculosis and Lung Disease. These countries include Estonia, Denmark, Henan and Zhejiang Provinces in China, Latvia, Iran, and the Russian oblasts of Ivanovo and Tomsk.

Author: Espinal, Marcos A., Kim, Sang Jae, Dye, Christopher, Raviglione, Mario C., Laszlo, Adalbert, Simonsne, Lone, Boulahbal, Fadila, Reniero, Ana, Hoffner, Sven, Rieder, Hans L., Binkin, Nancy, Williams, Rosamund
World, International aspects, Mycobacterium tuberculosis

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Evolution of Tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally

Article Abstract:

An evaluation is conducted on the prospects for detecting 70% of new sputum smear-positive cases and successfully treating 85% of these by the end of the year 2005 and for halving TB prevalence and deaths globally between 1990 and 2015. The findings indicate that the reduction of tuberculosis incidence, prevalence, and deaths by 2015 could be achieved in most of the world, but the challenge would be greatest in Africa and Eastern Europe.

Author: Dye, Christopher, Raviglione, Mario C., Watt, Catherine J., Bleed, Daniel M., Hosseini, S. Mehran
United States, Forecasts, trends, outlooks, Africa, Forecasts and trends, Mortality, Risk factors, Market trend/market analysis, Control

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Subjects list: Tuberculosis, Drug resistance in microorganisms, Microbial drug resistance
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