Gene transfer into CD4(super.+) T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses

Article Abstract:

Gene transfer into CD4 T lymphocytes is discussed as it relates to green fluorescent protein (GFP)-engineered, encephalitogenic T cells, which have been found to illuminate brain autoimmune responses. The technique of the study has implications of importance for development of safe/efficient therapeutic strategies involving gene-modified antigen-specific T lymphocytes. Topics include comparison of GFP with other marker techniques. Lewis rats were used.

Statistical Data Included, Research, Usage, Gene therapy, Genetic engineering, Brain, Fluorescence, Immunocytochemistry, T cells, Rats, Biotechnology

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Experimental autoimmune encephalomyelitis repressed by microglial paralysis

Article Abstract:

Ganciclovir blocked microglial activation in the facial nucleus in bone marrow chimeras to CD11b-HSVTK transgene mice upon axotomy and repressed the development of experimental autoimmune encephalomyelitis. Microbial paralysis inhibits the development and maintenance of inflammatory central nervous system (CNS) lesions.

Health aspects, Ganciclovir, Encephalomyelitis

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Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Article Abstract:

Research has been conducted on the central nervous system gene therapy. The targeting of the therapeutic factor to the central nervous system has been investigated and the details are discussed.

Central nervous system, Hematopoietic stem cells

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