Graft tolerance: a duel of two signals
Article Abstract:
A study in nonhuman primates has shown that mimicking the immune system's own mechanism for maintaining self-tolerance can make possible long-term survival of transplanted kidneys. Graft tolerance has been found to involve two signals and their interactions. The T killer cell and the B cell die when the death signal alone is received, but both differentiate to deliver immune responses if both signals arrive.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Generation of primary antigen-specific human T- and B-cell responses in immunocompetent SCID-hu mice
Article Abstract:
Research presented concerns the use of severe combined immunodeficiency (SCID) mice to more accurately replicate the physiological conditions in the human immune system. Topics addressed include human grafts to SCID mice, activation of human leukocytes in mice, and the study of antigen-specific immune responses.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake
Article Abstract:
Research presented concerns the role of neurotransmitter glucagon-like peptide-2 in the regulation of feeding behavior. Topics addressed include visceroceptive neurons, neuronal pathways, and neuroreceptors.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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