HIV-1 Drug Resistance in Newly Infected Individuals
Article Abstract:
People may become infected with strains of HIV that are already resistant to some AIDS drugs. In a study of 80 people who had recently become infected with HIV, 13 (16%) had a strain of the virus that was resistant to at least one AIDS drug. Ten had virus that was resistant to one or more nucleoside reverse transcriptase inhibitors, 6 had virus that was resistant to one or more nonnucleoside reverse transcriptase inhibitors, and 2 had virus that was resistant to at least one protease inhibitor. Three had virus that was resistant to more than one class of drug.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance, Part 3
Article Abstract:
Development of drug-resistant HIV and poor patient compliance with antiviral drug therapy could compromise the effectiveness of antiretroviral treatment for HIV infection. The rapid rate of mutation in HIV can produce drug-resistant virus even after antiviral treatment has been initiated. Antiviral therapy reduces viral loads in blood and, possibly, in genital fluids, which can reduce the risk of HIV transmission. Poor compliance with treatment protocols increases the risk of developing drug-resistant infection, which has important public health implications.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Resistance, Fitness, Adherence, and Potency: Mapping the Paths to Virologic Failure
Article Abstract:
There may be many reasons why AIDS drugs may not suppress HIV infection. Many HIV patients who take highly active antiretroviral therapy (HAART) experience almost complete suppression of the virus. However, blood levels of the virus can increase again despite the use of drugs. Two 1999 studies show that this is not necessarily caused by the fact that the virus has become resistant to the drugs. Patients may not be complying fully with the treatment and drug dosages may not be adequate.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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