HIV-protease inhibitors contribute to P-glycoprotein efflux function defect in peripheral blood lymphocytes from HIV-positive patients receiving HAART

Article Abstract:

Many protease inhibitors used to treat HIV infection inhibit P-glycoprotein. P-glycoprotein is found in many cells and is involved in drug uptake, distribution, and excretion.

Complications and side effects, HIV infection, Drug therapy, HIV infections

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Anti-HIV effects of chloroquine: Inhibition of viral particle glycosylation and synergism with protease inhibitors

Article Abstract:

The effects of chloroquine on glycosylation of HIV particles were tested in combination with protease inhibitors on HIV replication and on P-glycoprotein multidrug resistance protein-1. It was found that the inhibitory effects of chloroquine on HIV glycosylation are associated with synergistic in combination with protease inhibitors and the chloroquine / protease combination exerts inhibitory effects on P-glycoprotein and multidrug resistance protein-1 function.

United States, Glycosylation, Dosage and administration, Drug use, Chloroquine

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Atazanavir inhibits p-glycoprotein and multidrug resistance-associated protein efflux activity

Article Abstract:

An investigation on whether atazanavir (ATV) alone or in combination with other HIV-protease inhibitors (PIs) inhibits P-glycoprotein (p-gp) and multi-drug resistance-associated protein (MRP) function in normal peripheral blood lymphocytes (PBLs) is presented. Results reveal that the ATV is a possible substrate for P-gp and MRP in HIV-target cells such as normal PBLs and, like other PIs, competitively inhibits their efflux activity in a dose-dependent manner.

Product development, Drug therapy, Combination, Combination drug therapy, Atazanavir (Medication)

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