Spontaneous liver hematoma in pregnancy not clearly associated with preeclampsia: a case presentation and literature review
Liver hemorrhage, usually a complication of severe preeclampsia, may occur spontaneously. A case in which this happened prompted a review of the literature. No association with preeclampsia was found in 10 of 68 reported cases of liver rupture or hematoma during pregnancy. No mothers died, although a third or more of babies did. The data suggest that obstetricians should use the same guidelines for treatment as for liver trauma. Surgery should be performed when blood pressure cannot be stabilized, bleeding continues, pain increases, or there are signs of infection. A specialist in liver surgery should be available.
Publication Name: American Journal of Obstetrics and Gynecology
Severe liver damage caused by chlorzoxazone (Parafon Forte DSC) prompted the FDA to issue stronger warnings on the label. Chlorzoxazone, a skeletal muscle relaxant acting as a sedative on the central nervous system, has been available since 1958. There are no known other therapeutic benefits. Product labels are to refer to the unpredictable and even fatal side effects of this drug. Such liver toxicity and potential liver failure question the continued use of chlorzoxazone despite the issuance of increased warnings.
Publication Name: Medical Letter on Drugs and Therapeutics
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