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Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity

Article Abstract:

Results suggest that the requirement of the tetraspanin CD81 on hepatocytes for sporozite infectivity is indicated by the inability of Plasmodium yoelii sporozite to infect CD81-deficient mouse hepatocytes and that mouse and human CD81 antibody inhibition of hepatic development of P. yoelii and P. falciparum, respectively.

Author: Eling, Wijnand, Prenant, Michel, Silvie, Olivier, Rubinstein, Eric, Franetich, Jean-Francois, Belnoue, Elodie, Renia, Laurent, Hannoun, Laurent, Levy, Shoshana, Boucheix, Claude, Mazier, Dominique
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Netherlands, France, Cell hybridization, Sporozoa

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Hepatocyte growth factor and its receptor are required for malaria infection

Article Abstract:

Research shows that Plasmodium sporozoite entry into hepatocytes induces hepatocyte growth factor (HGF) secretion and subsequent infection of the hepatocytes. Data indicate that infection depends on the HGF receptor, MET, by HGF and that MET serves as a signal transducer to render host cell susceptible to infection.

Author: Rodriguez, Ana, Carrolo, Margarida, Giordano, Silvia, Cabrita-Santos, Laura, Corso, Simona, Vigario, Ana M., Silva, Susana, Leiriao, Patricia, Carapau, Daniel, Armas-Portela, Rosario, Comoglio, Paolo M., Mota, Maria M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Italy, Science & research, Spain, Portugal, Research, Cellular signal transduction, Cell receptors, Malaria

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Protection against 'Plasmodium falciparum' malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3

Article Abstract:

This article discusses liver-stage antigen 3, which is expressed in mosquito and liver-stage parasites. The authors maintain a chimpanzee was immunized with liver-stage antigen 3, which provided protection against large numbers of 'Plasmodium falciparum' sporozoites.

Author: Dubreuil, Guy, Daubersies, Pierre, Thomas, Alan W., Millet, Pascal, Brahimi, Karima, Langermans, Jan A.M., Ollomo, Benjamin, Mohamed, Lbachir Ben, Slierendregt, Bas, Eling, Wijnand, Van Belkum, Alex, Meis, Jacques F.G.M., Guerin-Marchand, Claudine, Cayphas, Sylvie, Cohen, Joe, Gras-Masse, Helene, Druilhe, Pierre
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Immunization, Plasmodium falciparum

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Subjects list: United States, Infection, Physiological aspects, Liver cells, Hepatocytes, Plasmodium, Plasmodium (Protozoa)
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