High frequency of the GWG (Pro Trp) envelope variant of HIV-1 in Southeast Brazil
Article Abstract:
HIV patients in Brazil may be infected with a viral variant formerly found in several patients in Japan, France, and Brazil through direct gene sequencing. Researchers in Southeast Brazil used restriction fragment length polymorphism (RFLP) testing in 75 HIV patients to determine the frequency of the GWG gene sequence in HIV. Fifty-seven percent of tested patients were infected with the variant virus. Seventy-two percent of women and 32% of men were so infected. Development of a successful HIV vaccine requires that all viral variants are included, providing the highest degree of protection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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V3 sequence diversity of HIV-1 subtype E in infected mothers and their infants
Article Abstract:
HIV-infected infants appear to have different variants of HIV than their mothers. Researchers analyzed the genetic sequence of the V3 region of HIV subtype E from blood samples of 17 HIV-infected Thai mothers and their infants. Nine of the infants developed immunosuppression within the first year of life. These infants were infected with different HIV variants than their mothers, which was not seen in the uninfected infants. HIV subtype E is the predominant form of HIV in Thailand.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Potential SECIS elements in HIV-1 strain HXB2
Article Abstract:
A researcher has used a computer-based viral sequence analysis to find genetic regions within a strain of HIV likely to encode the amino acid selenocysteine. Proteins which contain this amino acid are rare, but have important physiologic functions. This computerized search scheme identified a region in the HIV genetic code called a selenocysteine insertion sequence (SECIS).
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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