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Cyclophosphamide versus placebo in scleroderma lung disease

Article Abstract:

A double-blind, randomized, placebo-controlled trial was conducted to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence of active alveolitis and scleroderma-related interstitial lung disease. It was found that one year of oral cyclophosphamide in patients with symptomatic scleroderma-related interstitial lung disease had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and the health-related quality of life.

Author: Tashkin, Donald P.; Elashoff, Robert; Clements, Philip J.; Goldin, Jonathan; Roth, Michael D.; Furst, Daniel E., Arriola, Edgar; Silver, Richard; Strange, Charlie; Bolster, Marcy; Seibold, James R., Riley, David J.; Hsu, Vivien M.; Varga, John; Schraufnagel, Dean E., Theodore, Arthur; Simms, Robert; Wise, Robert; Wigley, Fredrick; White, Barbara; Steen, Virginia; Read, Charles; Mayes, Maureen; Parsley, Ed D.O.; Mubarak, Kamal, Connolly, Kari; Golden, Jeffrey; Olman, Mitchell; Fessler, Barri; Rothfield, Naomi; Metersky, Mark
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Drug therapy, Quality of life, Systemic scleroderma, Scleroderma (Disease), Lung diseases

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Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever

Article Abstract:

A study examines the efficacy of a short course of the antimicrobial agent doxycycline in preventing tick-borne relapsing fever (TBRF) after high-risk activities in an area where TBRF is endemic. Results demonstrate that treatment with doxycycline is safe and efficacious in preventing TBRF after suspected exposure to ticks in a high-risk environment.

Author: Hasin, Tal, Cohen, Regev, Davidovitch, Nadav, Dagan, Tsachi; Romem, Ayal, Orr, Nadav; Klement, Eyal, Lubezky, Nir; Kayouf, Raid; Sela, Tamar, Keller, Nathan; Derazne, Estela; Halperin, Tamar, Yavzori, Miri; Grotto, Itamar; Cohen, Dani
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Care and treatment, Diagnosis, Prevention, Jarisch-Herxheimer reaction

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