Human HIV vaccine trials: does antibody-dependent enhancement pose a genuine risk?

Article Abstract:

In vitro studies showed that human immunodeficiency virus (HIV)-specific human antibodies can elicit HIV growth. The veracity of its use in vaccination is thus being questioned because of the probability of the same results happening in vivo. The antibody-enhanced activity has been equated to partial immunity and disease severity, as documented in studies on Dengue Fever. The process involves several viral receptor binding and varies among virus types. This subsequently enhances viral growth and redirects pathologic effects. It can be prevented by selective or generalized induction of viral immunity.

AIDS vaccines

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Joseph-Alexandre Auzias-Turenne, Louis Pasteur, and early concepts of virulence, attenuation, and vaccination

Article Abstract:

Adrian Loir, assistant to Louis Pasteur, relates in a biographical series on him that Pasteur secretly read the work of Joseph-Alexandre Auzias-Turenne "La Syphilization" and used it as a basis of much of his vaccine research. Very little evidence exists to support Loir's claims, but Pasteur's research did use the same diseases and focus on the same issues that Auzias had addressed. Pasteur's secrecy about this influence probably related to the fact that much of Auzias' work on syphilis patients had been ridiculed and discredited.

History, Medical research, Vaccines, Pasteur, Louis, Auzias-Turenne, Joeph-Alexandre

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HIV-1 entry inhibitors: evading the issue

Article Abstract:

HIV-1 entry into cells is an attractive target for new antiviral agents, but some wonder whether inhibitors aimed at the CCR5 coreceptor force HIV-1 to evolve more virulent versions of itself. With CD4, CCR5 and CXCR4, coreceptors on the cell surface, mediate virus binding and membrane fusion. CCR5 is apparently dispensable for normal health, but CXCR4 is not.

United States, Cell membranes, Plasma membranes, Anti-HIV agents

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