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Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction

Article Abstract:

Immediate angioplasty may not be more effective than thrombolytic therapy for myocardial salvage, or preserving heart muscle tissue, in patients who have suffered a heart attack. Thrombolytic therapy involves treatment with drugs to break up a blood clot. Among 103 patients who suffered a heart attack, 47 underwent angioplasty and 56 were treated with tissue plasminogen activator. Of the patients who suffered an anterior heart attack, an average of 31% of the left ventricle was salvaged in patients who underwent angioplasty, compared with 27% in the patients treated with tissue plasminogen activator. Myocardial salvage was an average of 7% among the patients who underwent angioplasty for a heart attack in another location in the heart, compared to an average of 5% among those treated with thrombolytic drugs.

Author: Reeder, Guy S., Holmes, David R., Gersh, Bernard J., Bailey, Kent R., Gibbons, Raymond J., Hopfenspirger, Mona R.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1993
Tissue plasminogen activator

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Primary Coronary Angioplasty vs Thrombolysis for the Management of Acute Myocardial Infarction in Elderly Patients

Article Abstract:

Elderly heart attack patients who receive coronary angioplasty may have slightly lower mortality rates than those who receive thrombolytic drugs. Angioplasty and thrombolytic drugs are used to open clogged arteries. In a study of 18, 645 aged heart attack patients who received thrombolytic drugs and 2,038 who received angioplasty, 30-day and one-year mortality rates were slightly lower in those who received angioplasty. However, the difference in mortality rates at one year was only 12%.

Author: Gersh, Bernard J., Schulman, Kevin A., Johnson, Ayah E., Berger, Alan K., Pirzada, Sarmad, Breall, Jeffrey A., Every, Nathan H.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
Statistical Data Included, Mortality, Cardiac patients, Transluminal angioplasty, Balloon angioplasty

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Rescue angioplasty after failed thrombolytic therapy for acute myocardial infarction

Article Abstract:

A multicenter trial in the United Kingdom is conducted for comparing rescue percutaneous coronary intervention (PCI) with repeated thrombolysis. Event-free survival after failed thrombolytic therapy is significantly higher with rescue PCI than with repeated thrombolysis or conservative treatment.

Author: Henderson, Robert A., Davis, John, Gershlick, Anthony H., Banning, Adrian, Baumbach, Andreas, Stephens-Loyd, Amanda, Pitt, Michael, Man Fai Shiu, Hughes, Sarah, Schofield, Peter, Abrams, Keith R., de Belder, Adam, Dawkins, Keith D., Stevens, Suzanne E., Uren, Neal G., Oldroyd, Keith G., Wilcox, Robert
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
United Kingdom, Usage

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Subjects list: Care and treatment, Evaluation, Heart attack, Angioplasty, Patient outcomes, Thrombolytic therapy
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