Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue

Article Abstract:

Research is presented on interaction between antigen-presenting cells and active naive T and B lymphocytes in secondary lymphoid organs, which are essential for initiating immune responses. Issues discussed include the immune response to organ transplants and the permanent acceptance of these grafts which is shown to be due to immunological 'ignorance.'

Author: Lakkis, Fadi G., Arakelov, Alexandr, Konieczny, Bogumila T., Inoue, Yoshihiko
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Lymphocytes, Antigens, Lymphatic diseases, Immunologic diseases

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Hitting the reset button for immune tolerance

Article Abstract:

Research presented concerns the immunological issues that complicate organ transplantation, focusing on the physiology of graft tolerance or rejection. Topics addressed include chimerism, migratory cells, and immune tolerance.

Author: Kirk, Allan D.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Graft rejection

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Immunity or tolerance: opposite outcomes of microchimerism from skin grafts

Article Abstract:

Research in immunological tolerance is presented, focusing on the role of migrating 'passenger' leukocytes that can enter the host's circulatory system and facilitate graft tolerance. Topics addressed include immunochemistry and chimerism in skin grafts.

Author: Anderson, Colin C., Matzinger, Polly
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Skin-grafting, Skin grafts, T cells

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Subjects list: Research, United States, Physiological aspects, Transplantation of organs, tissues, etc., Organ transplantation, Tissue transplantation, Transplantation, Cell migration, Immunological tolerance, Immunologic tolerance
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