In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
Article Abstract:
Research indicates that caveolin-1 scaffolding domain is able to selectively regulate endothelial nitric oxide synthase (eNOS) signal transduction, resulting in the suppression of vascular leak and acute inflammation similar to a glucocorticoid. Implications for therapeutic approaches via small-molecule mimicry are discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
Article Abstract:
Research presented concerns the regulation of penile erection, focusing on the impact of Rho-kinase antagonism on cavernosal tissue, smooth muscle cells, and blood pressure in rats. Findings suggest that Rho-kinase antagonism initiates an erectile response independently of nitric oxide.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids
Article Abstract:
Researchers have discovered a peptide produced by monocytes in the presence of glucocorticoids that has anti-inflammatory properties. Thymosin beta4 sulfoxide inhibited neutrophil chemotaxis and limited edema in a study in mice.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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