Inhibition of cervical ripening by local application of cyclooxygenase 2 inhibitor
Article Abstract:
A drug called nimesulide may be able to prevent premature delivery, according to a study in rats. The drug is applied to the cervix and appears to inhibit cervical ripening, which is a softening of the cervix that occurs prior to delivery.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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Inhibition of cyclooxygenase but not nitric oxide synthase influences effects on the human omental artery of the thromboxane A(sub 2) mimetic U46619 and 17beta-estradiol
Article Abstract:
Blood vessel relaxation caused by estrogen does not involve nitric oxide production. Instead, it appears to involve the production of substances that inhibit contraction.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats
Article Abstract:
The drug nimesulide delayed the onset of labor in a study of rats. This drug inhibits the enzyme cyclooxygenase-2. Drugs that inhibit cyclooxygenase-1 or nitric oxide synthase were not effective in delaying labor onset.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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