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Inhibition of cervical ripening by local application of cyclooxygenase 2 inhibitor

Article Abstract:

A drug called nimesulide may be able to prevent premature delivery, according to a study in rats. The drug is applied to the cervix and appears to inhibit cervical ripening, which is a softening of the cervix that occurs prior to delivery.

Author: Saade, George R., Garfield, Robert E., Bukowski, Radek, MacKay, Lynn, Fittkow, Cordula, Shi, Leili
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001

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Inhibition of cyclooxygenase but not nitric oxide synthase influences effects on the human omental artery of the thromboxane A(sub 2) mimetic U46619 and 17beta-estradiol

Article Abstract:

Blood vessel relaxation caused by estrogen does not involve nitric oxide production. Instead, it appears to involve the production of substances that inhibit contraction.

Author: Saade, George R., Garfield, Robert E., Vedernikov, Yuri P., Belfort, Michael A.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
Physiological aspects, Blood vessels, Estradiol, Vasodilation

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The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats

Article Abstract:

The drug nimesulide delayed the onset of labor in a study of rats. This drug inhibits the enzyme cyclooxygenase-2. Drugs that inhibit cyclooxygenase-1 or nitric oxide synthase were not effective in delaying labor onset.

Author: Saade, George R., Garfield, Robert E., Bukowski, Radoslaw, McKay, Lynn, Shi, Shao-Qing
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001

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Subjects list: Evaluation, Prevention, COX-2 inhibitors, Premature labor
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